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KMID : 0377219940190010048
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Medical Journal of Chosun Univercity
1994 Volume.19 No. 1 p.48 ~ p.57
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A Clinical Evaluation of Micral-Test^TM for Screening of Microalbuminuria
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Moon Dae-Soo
Lee Kook-Il
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Abstract
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The excretion of small quantities of urinary albumin (microalbuminuria) might the earliest clinical sign of incipient diabetic nephropathy and important predictor of renal failure in diabetes. Currently methods available to detect microalbuminuria were not suitable for routine screening. A test strip (Micral-Test_TM : Boehringer Mannheim GmbH, Germany) based on dry immnunochemical principles had recently been developed which allows semiquantitative detection of urinary low albumin concentration. We measured microalbuminuria by Micral-Test_TM and compared with any other items. The results were summerized as follows : 1. The relationships of the duration of diabetes to microalbuminuria was low positive association (r=0.332l). 2. Results obtained by Micral-Test_TM correlated closely with values obtained by rate nephelometry (r=0.7998). 3. There were statistically significant difference in BUN between positive and negative results of Micral-Test_TM(p＜0.05), but no significant difference in FBS TG, total cholesterol, creatinine and BP . 4. There were statistically significant difference in BUN, creatinine BP between positive and negative results of N-Multistix SG_TM(p＜0.001, p＜0.01, p＜0.05), but no significant difference in FBS, TG, total cholesterol. 5. The detection discrepancy rate of albuminuria in diabetes between Micral-Test_TM and N-Multis- tix SG_TM was 12.9%. In conclusioin, Micral-Test_TM was a good screening method for easy and quick detection of microalbuminuria and monitoring the development of urinary albumin excretion in the microalbuminuric range.
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KEYWORD
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Microalbuminuria, Micral-Test^TM, Diabetes
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